San Jose Del Pacifico is a small town in the Sierra Sur which is primarily famous for its magic mushrooms. The town and greater area also have a variety of trails to explore and cabins to stay in. Unlike many towns in Oaxaca’s mountain, San Jose is one of the most easy to get (as it is is en route to the coast and many collectivos go through).
Several private companies offer vans to San Jose del Pacifico, including Eclipse 70. They, and several other bus lines, can be found near the corner of Bustamante and Rayon, roughly three blocks south of the Zocalo.